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Dr. Adams
04-04-2009, 06:15 PM
"Patients with migraine, whether episodic or chronic, are more apt to have post-traumatic stress disorder (PTSD) than the general population. Furthermore, the presence of PTSD in migraineurs is independently associated with greater headache-related disability.

In women, the lifetime prevalence of PTSD is twice that of men. Despite the clinical perception that military combat is the most common etiology, the most common causes of PTSD are interpersonal traumas, including sexual abuse.

The implications are such that abuse causes not just psychological distress from PTSD but also physical pain such as migraine, and there is an increased disability seen in those migraineurs with PTSD than those without PTSD.

The results also show that, in migraineurs with depression, PTSD is more common in those with chronic daily headache than in those with episodic migraine, suggesting that PTSD is a risk factor for migraine chronification in those migraineurs with depression.

Dual action antidepressants have efficacy for both migraine and PTSD, but the serotonin-reuptake inhibitor antidepressants regarded as first-line treatments for PTSD have performed poorly for migraine prophylaxis."

Headache 2009;49:541-554.