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Questions
of the Week
October
Through December, 1999
October 4, 1999
Q "I
have back spasm and my family doctor put me on Valium 5mg three times
a day for two weeks as part of the treatment. I understand that Valium
is highly addictive and have not taken the medication. Can you provide
me with some thoughts on this or similar drugs?"
A The
benzodiazepines, and their derivatives, are use mainly in the
treatment of anxiety, insomnia and panic disorder. They are also used
for acute stress (an emotional upheaval) and often pre-surgically.
They are safe and effective, and their likelihood of causing
dependence is based upon dosage and length of time for treatment.
Those with past histories of other drug or alcohol dependence may be
more vulnerable to dependence upon the benzodiazepines. Some studies
indicate that patients have taken the benzodiazepines for months or
years, usually maintaining or actually reducing intake.
When dependence occurs it is due to the
action of the drug at nerve receptors alongside receptors for the
inhibitory neurotransmitter called gamma-aminobutyric acid (GABA).
With repeated use, the benzodiazepines receptors can adapt to the
drug's presence, and the sensitivity of the receptors change. Then if
the drug is abruptly withdrawn, the patient can become anxious,
agitated or have difficulty sleeping. This is uncomfortable but not
life threatening. There are, however, rare instances of withdrawal
seizures, depression or psychotic states.
There is no proof, but some clinicians
believe that potent benzodiazepines with short half lives (Xanax or
Ativan) create faster dependence (in comparison to Valium, Librium or
Serax which have longer half-lives in the system).
Patients hear these tales, become fearful
of what the patient calls "addiction" and those prescribing
often become equally concerned about long term use. Interestingly,
abuse of these drugs is uncommon, most are prescribed for short term
treatment, but, as noted, there are data to indicate that even long
term monitored use can be entirely safe. It is always best to discuss
these fears, beliefs and concerns with who is prescribing the
benzodiazepines.
October 11, 1999
Q "I
have never been entirely clear on whether addiction is psychological
or physical or both, and frankly, some of my friends use drugs and/or
alcohol to such an extent that I would think of them as having a
problem. In general can you give me an overview of this problem?"
A Substance-Related
Disorders refer to not only the chemical upon which abuse or
dependence has occurred, but also the nature of the impact of the
substance use has had upon the individual. This can vary from abuse
to dependence and from hallucinations to delusions to delirium.
Substance abuse or dependence can result in mood, anxiety, sleep and
sexual disorders as well as problems arising from withdrawal. Agents
ranging from alcohol to cocaine to cannabis, hallucinogens, inhalants,
opioids, phencyclidine, inhalants and sedatives can be of concern.
November 1, 1999
Q "We
have no alcoholism in the family, and frankly all I know about it is
that it is a terrible problem and results in DUIs, deaths and family
violence. Are there mental disorders that arise from alcoholism or
just problems in behavior?"
A When
considering substance related disorders like alcohol abuse or
dependence, you need to think in terms of the moods and behaviors that
arise from intoxication as well as the physical problems which arise
from withdrawal from the substance. The morbidity and mortality from
alcohol, the most frequently used brain depressant, with 60% of males
and 30% of females having at least one alcohol related adverse life
event. There are psychological disorders that arise from the
dependence upon alcohol and its abuse. These include dementia,
amnesia, delusions, hallucinations, mood disorder, sleep disorder,
anxiety disorder and sexual disorder. Not surprisingly, alcohol,
the most commonly abused substance, is often an attempt at
self-medicating the very problems that it creates.
November 8, 1999
Q "I
typically use hydrocodone for my post-surgical patients. I feel that
this is an effective drug although it can be habituating. But I wonder
if I should combine it with antidepressants or some other form of
therapy since many of these patients have the symptoms of depression
including sleep problems and anxiety. Care to comment?"
A Opioid-Related
Disorder (including syntheric opiates) can be associated with abuse
and dependence. The discontinuation of the medication can be related
to withdrawal and overuse can be associated with intoxication, and
dependent upon patient and dosage, psychotic symptoms with
hallucinations and/or delusions. The medications themselves can create
their own clinical manifestation of mood disorder. Sleep disorder due
to changes in sleep architecture and sexual dysfunction may occur.
November 15, 1999
Q "I read all
of these psychological articles about "addiction to the
internet", and I have some doubts. I do know that I personally am
drawn to the auction sites and even considered getting one of those
pagers that tell me when bids are exceeded, etc. Is this internet
thing really addictive?"
A Weeks
ago we discussed Impulse
Control Disorders, one of which was Pathological Gambling. These
disorders to not rise to the criteria of addiction, but they can
represent a major disruption to occupational and interpersonal
functioning. The individual who feels impelled to bid on auctions to
the point of disruption of adaptive daily functioning becomes
preoccupied, often increasing risk, and fails attempts unsuccessfully
to stop the behavior. They become involved in "chasing their
losses", returning repeatedly to the situation, feeling driven to
engage in the behavior and may borrow from others to perpetuate the
pattern. While such individuals appear more likely to develop stress
related physical disorders, there is no evidence that they are more
prone to substance related disorders.
November 21, 1999
Q
"I take Xanax for my anxiety disorder. I take it according to
schedule and in recent weeks this has been decreased because my
symptoms have been reduced. I am on a small maintenance amount and
hope to be off the drug soon. When the drug is stopped, I am concerned
that I will be left with an addiction or addictive personality."
A There
are several sedative, hypnotic and anxiolytic disorders. Hypnotics are
used for treatment of sleep disorders, anxiolytics are used for the
treatment of a range of anxiety disorders. All three groups of agents,
if not properly regulated can result in dependence, and all three are
open to abuse. In some cases intoxication, withdrawal, delirium,
amnesia, mood, sleep, sexual and other symptom patterns may arise. In
some cases hallucinations may occur even though the individual is
aware that the hallucinations are caused by the medication (does not
believe the hallucinations to be real). However, these medications,
when dispensed and used appropriately, can be quite effective as an
adjunct to the treatment of a range of disorders and should be taken
according to guidelines and not avoided due to fear.
November 28, 1999
Q "My
uncle is 67 and has high blood pressure. He denies the seriousness of
his problem. We also suspect that he (a former commanding officer for
three tours in Vietnam) has continued to use a variety of drugs. We
think he has Alzheimer's Disease. His memory is very bad and becoming
worse. When I asked the Veteran's Hospital if this were Alzheimer's,
they only said `perhaps' as though there were other causes. Can you
tell me of other possible causes?"
A Dementia
comprises multiple cognitive (thinking) deficits including the
inability to retain new information and recall previously learned
information. It arises not only in Alzheimer's Disease, but in
Vascular Dementia where the blood supply to the brain in interrupted
or blocked. Dementia can result from the intake (intentionally or
accidentally) of substances and can also be due to a variety of
medical conditions that effect the central nervous system. There can
be mood changes, behavioral disturbances, delusions and delirium
(reduced clarity of awareness of the environment).
In toto, however, this is not something
that you should, or can, personally diagnose. His symptoms, and your
concern, should suggest to you that he be appropriately evaluated by
someone who is, or can become, familiar with his history, including
the drug abuse and problems with compliance with his anti-hypertensive
regimen.
December 6, 1999
Q "If
an individual has memory impairment, does this necessarily mean
Alzheimer's Disorder?"
A Amnestic
Disorder, the impairment in the ability to learn new information or
recall previously learned material, can be transient or chronic. It
can be substance induced or can be the result of a disease process. It
is only one component of the dementia seen in Alzheimer's Disorder (in
which there may be language disturbance, inability to carry out motor
activities (apraxia), failure to recognize familiar objects (agnosia)
and/or inability to organize, plan, etc (executive functioning).
Amnestic Disorder is confined to memory difficulty and is not
associated with the mood, delusional and behavioral complications of
Alzheimer's Disorder.
December 13, 1999
Q "You
talked about vascular dementia and Alzheimer's disease, but dementia
also comes from other diseases as well, does it not?"
A Dementia
presented as memory impairment (both inability to learn new material
and to recall old material), along with cognitive problems such as
language disturbance (aphasia), inability to carry out motor
activities (apraxia) or inability to recognize objects (agnosia) can
arise from HIV Disease, Head Trauma, Parkinson's Disease, Huntington's
Disease, Pick's Disease, Creutzfeldt-Jakob Disease and others.
Dementia can also be the longstanding and perhaps permanent impact of
substances ingested. Obviously,dementia can, for some individuals, be
the combined result of multiple factors.
December 20, 1999
Q "I
saw a movie recently about Tourette's Disorder. It was a comedy, and I
did not learn a great deal. What is this disorder?"
A Tourette's
Disorder is a tic disorder in which there are multiple motor and one
or more vocal tics present during the course of the disorder. The
motor or vocal tic need not be present concurrently. The tics often
occur in bouts almost every day and for a period of greater than one
year. There are no tic-free periods exceeding three months in order to
be diagnosed with Tourette's Disorder. The onset is before the age of
18.
December 27, 1999
Q
"I went to school with a boy who would wince and shrug his
shoulder as though flinching. He would do this several times a day.
When I went to college, I sat next to a fellow who would give a series
of verbal noises...much like saying "huh?" several times.
What is this problem?"
A Chronic
motor or vocal tic disorder are recurrent, involuntary movements or
vocalizations over which the individual appears to have no control. It
is usually diagnosed when the behavior has been present for at least a
year and during which time there has been no period exceeding three
months when the problem was not present. The onset is prior to
adulthood and is not caused by another disease process or substance
abuse. The person is most often distressed by the symptoms and
social/occupational functioning can be impaired. There are
psychological and medical approaches to treating a motor or vocal tic
disorder.
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